Research background · Updated November 1, 2026
Humanin Research: Publications, Study Types and Background
Short answer
Humanin. As of November 1, 2026, PubMed indexes 550 records matching Humanin, the earliest from 2001; 183 were published in 2021–2025 and 86 are reviews. ClinicalTrials.gov lists 7 registered studies matching the compound.
- PubMed records
- 550
- Earliest record
- 2001
- Published 2021–2025
- 183
- Reviews
- 86
- Animal-only studies
- 140
- Registered studies
- 7
Publications per year, 2006–2025
362 records in 2016–2025 against 154 in 2006–2015; the busiest year was 2021, with 44.
See the numbers
| Year | PubMed records |
|---|---|
| 2006 | 15 |
| 2007 | 7 |
| 2008 | 13 |
| 2009 | 17 |
| 2010 | 14 |
| 2011 | 13 |
| 2012 | 13 |
| 2013 | 21 |
| 2014 | 21 |
| 2015 | 20 |
| 2016 | 21 |
| 2017 | 30 |
| 2018 | 31 |
| 2019 | 36 |
| 2020 | 41 |
| 2021 | 44 |
| 2022 | 40 |
| 2023 | 41 |
| 2024 | 41 |
| 2025 | 37 |
Study types
| All PubMed records | 550 |
|---|---|
| Reviews | 8616% |
| Animal studies (no human subjects indexed) | 14025% |
| Indexed as clinical trials | 81% |
| Registered on ClinicalTrials.gov | 7 |
Categories overlap and follow PubMed’s own indexing; recent records may not be indexed yet.
Primary research directions
What 1 of the most-cited and most recent Humanin papers report, in their own authors’ terms. Each line links the paper it came from.
Mitochondrial-derived peptide
This review describes humanin as an endogenous mitochondrial-derived peptide and summarizes experimental work in which it antagonized mechanisms associated with Alzheimer's disease, including amyloid plaque accumulation.
ReviewNiikura T 2022Biochimica et biophysica actaPMID 34626746
Most-studied topics
The Medical Subject Headings (MeSH) PubMed indexers most often marked as a main topic, across 400 of the 550 records. They describe what the literature is about, not what Humanin does.
- Intracellular Signaling Peptides and Proteins184 papers
- Mitochondria65 papers
- Neuroprotective Agents34 papers
- Apoptosis31 papers
- Alzheimer Disease29 papers
- Neurons26 papers
- Mitochondrial Proteins21 papers
- Amyloid beta-Peptides18 papers
Key papers
Earliest indexed record
Hashimoto Y (2001). Biochemical and biophysical research communications.
PMID 11327724Most-cited paper · 523 citations
Guo B (2003). Nature.
PMID 12732850Most-cited #2 · 385 citations
Migeotte I (2006). Cytokine & growth factor reviews.
PMID 17084101Most-cited #3 · 221 citations
Lee C (2013). Trends in endocrinology and metabolism: TEM.
PMID 23402768
Citation counts from NIH iCite, among the 400 records sampled. Titles are left out; open each record on PubMed to read it.
Identity
| CAS | 330936-69-1 |
|---|---|
| Molecular formula | C119H204N34O32S2 |
| Molecular weight | 2687.2 g/mol |
| Synonyms | Humanin, H975EUX36G, DTXSID70186749, RefChem:146895, DTXCID60109240 |
Identity data from PubChem, retrieved November 1, 2026, on the Humanin page.
How these numbers were counted
- PubMed search, run November 1, 2026:
humanin[tiab]re-run it. Study types add PubMed’s own filters (review, clinical trial, animals not humans). - Topics: MeSH major-topic headings counted across up to 400 of the matching records; headings for study set-up (species, sex, age) are left out.
- Citations: NIH iCite citation counts for the same records.
- ClinicalTrials.gov search:
humaninre-run it. Any phase, any status.
This page reports what has been published and what papers say they found, with each source linked. It gives no dosing or usage information, and nothing here is a reason to use Humanin outside a laboratory.
Wholesale supply
Humanin, sourced to order for research.
Not held in the listed catalog. Tell us the vial size and the number of vials and we come back with availability, documentation and pricing in writing.
Humanin research questions
How much research has been published on Humanin?
PubMed indexes 550 records matching Humanin (searched November 1, 2026), including 86 reviews and 8 records indexed as clinical trials. 183 were published in the five years 2021–2025.
When was Humanin first described in the literature?
The earliest PubMed record matching Humanin is from 2001 (Hashimoto Y, Biochemical and biophysical research communications, PMID 11327724).
What topics does the Humanin literature cover?
The subject headings PubMed indexers most often marked as a main topic of Humanin papers are Intracellular Signaling Peptides and Proteins, Mitochondria, Neuroprotective Agents, Apoptosis. These describe what the literature is about. Findings from individual papers, with their sources, are summarized on this page.
Is Humanin sold for human use?
No. Vanta Foundry supplies it for laboratory research use only. Not for human or veterinary use, and not a drug, food, cosmetic or dietary supplement.
Where can I buy Humanin wholesale for research?
We source Humanin to order rather than stock it. Tell us the vial size and number of vials on WhatsApp or by email and the quote confirms availability, documentation and pricing.
Research materials supplied by Vanta Foundry are for laboratory research use only. They are not for human or veterinary use and are not drugs, foods, cosmetics or dietary supplements. Websites and payment processing are business services for research-supply brands.
All compounds: research peptide publication statistics.