Research background · Updated November 1, 2026
Kisspeptin Research: Publications, Study Types and Background
Short answer
Kisspeptin is listed as decapeptide corresponding to residues 45–54 of human metastin (kisspeptin). As of November 1, 2026, PubMed indexes 3,439 records matching Kisspeptin, the earliest from 2000; 1,057 were published in 2021–2025 and 805 are reviews. ClinicalTrials.gov lists 45 registered studies matching the compound.
- PubMed records
- 3,439
- Earliest record
- 2000
- Published 2021–2025
- 1,057
- Reviews
- 805
- Animal-only studies
- 1,708
- Registered studies
- 45
Publications per year, 2006–2025
2,341 records in 2016–2025 against 1,377 in 2006–2015; the busiest year was 2022, with 275.
See the numbers
| Year | PubMed records |
|---|---|
| 2006 | 42 |
| 2007 | 66 |
| 2008 | 98 |
| 2009 | 136 |
| 2010 | 153 |
| 2011 | 127 |
| 2012 | 155 |
| 2013 | 208 |
| 2014 | 197 |
| 2015 | 195 |
| 2016 | 221 |
| 2017 | 227 |
| 2018 | 240 |
| 2019 | 255 |
| 2020 | 242 |
| 2021 | 252 |
| 2022 | 275 |
| 2023 | 189 |
| 2024 | 204 |
| 2025 | 236 |
Study types
| All PubMed records | 3,439 |
|---|---|
| Reviews | 80523% |
| Animal studies (no human subjects indexed) | 1,70850% |
| Indexed as clinical trials | 612% |
| Registered on ClinicalTrials.gov | 45 |
Categories overlap and follow PubMed’s own indexing; recent records may not be indexed yet.
Primary research directions
What 2 of the most-cited and most recent Kisspeptin papers report, in their own authors’ terms. Each line links the paper it came from.
Reproductive axis
This review describes hypothalamic kisspeptin neurons as the nodal regulatory centre of reproductive function and discusses evidence that they also take part in the circuits governing energy balance.
ReviewNavarro VM 2020Nature reviews. EndocrinologyPMID 32427949
Puberty and ovulation
This review describes the roles of kisspeptin and neurokinin B in puberty and reproduction, and reports that kisspeptin's role as a natural inducer of ovulation has led to research into it as a trigger of oocyte maturation in IVF.
ReviewKoysombat K 2025Physiological reviewsPMID 39813600
Most-studied topics
The Medical Subject Headings (MeSH) PubMed indexers most often marked as a main topic, across 400 of the 3,439 records. They describe what the literature is about, not what Kisspeptin does.
- Kisspeptins226 papers
- Receptors, G-Protein-Coupled64 papers
- Gonadotropin-Releasing Hormone54 papers
- Reproduction52 papers
- Tumor Suppressor Proteins52 papers
- Neurons32 papers
- Brain26 papers
- Hypothalamus26 papers
Key papers
Earliest indexed record
Feingold KR (2000). .
PMID 25905176Most-cited paper · 1,212 citations
Kotani M (2001). The Journal of biological chemistry.
PMID 11457843Most-cited #2 · 910 citations
Gottsch ML (2004). Endocrinology.
PMID 15217982Most-cited #3 · 575 citations
Pinilla L (2012). Physiological reviews.
PMID 22811428
Citation counts from NIH iCite, among the 400 records sampled. Titles are left out; open each record on PubMed to read it.
Identity
| Synonyms and codes | KP-10, Metastin 45-54, Human kisspeptin-10 |
|---|---|
| Description | Decapeptide corresponding to residues 45–54 of human metastin (kisspeptin) |
| Supplied form | Lyophilized powder |
| CAS number | 374675-21-5 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 g/mol |
As published by Vanta Labs, with its sources, on the Kisspeptin page.
How these numbers were counted
- PubMed search, run November 1, 2026:
kisspeptin[tiab] OR kisspeptins[tiab]re-run it. Study types add PubMed’s own filters (review, clinical trial, animals not humans). - Topics: MeSH major-topic headings counted across up to 400 of the matching records; headings for study set-up (species, sex, age) are left out.
- Citations: NIH iCite citation counts for the same records.
- ClinicalTrials.gov search:
kisspeptinre-run it. Any phase, any status.
This page reports what has been published and what papers say they found, with each source linked. It gives no dosing or usage information, and nothing here is a reason to use Kisspeptin outside a laboratory.
Wholesale supply
Kisspeptin for research, documented lot by lot.
10mg vials, with a published report printing 99.791% HPLC purity. Every wholesale lot comes with its certificate of analysis, and your quote names the lot. Pricing on inquiry.
Kisspeptin research questions
How much research has been published on Kisspeptin?
PubMed indexes 3,439 records matching Kisspeptin (searched November 1, 2026), including 805 reviews and 61 records indexed as clinical trials. 1,057 were published in the five years 2021–2025.
When was Kisspeptin first described in the literature?
The earliest PubMed record matching Kisspeptin is from 2000 (Feingold KR, , PMID 25905176).
What topics does the Kisspeptin literature cover?
The subject headings PubMed indexers most often marked as a main topic of Kisspeptin papers are Kisspeptins, Receptors, G-Protein-Coupled, Gonadotropin-Releasing Hormone, Reproduction. These describe what the literature is about. Findings from individual papers, with their sources, are summarized on this page.
What is the regulatory status of Kisspeptin?
Kisspeptin-10 is not listed as an approved drug in the FDA's Drugs@FDA database (searched 24 September 2026).
Is Kisspeptin sold for human use?
No. Vanta Foundry supplies it for laboratory research use only. Not for human or veterinary use, and not a drug, food, cosmetic or dietary supplement.
Where can I buy Kisspeptin wholesale for research?
From the Vanta Foundry wholesale catalog: add it to your list, choose sizes and the number of vials, and send it on WhatsApp or by email. Every wholesale lot comes with a certificate of analysis.
Research materials supplied by Vanta Foundry are for laboratory research use only. They are not for human or veterinary use and are not drugs, foods, cosmetics or dietary supplements. Websites and payment processing are business services for research-supply brands.
All compounds: research peptide publication statistics.