Research background · Updated November 1, 2026
DSIP Research: Publications, Study Types and Background
Short answer
DSIP is listed as nonapeptide (9 amino acids). As of November 1, 2026, PubMed indexes 462 records matching DSIP, the earliest from 1977; 7 were published in 2021–2025 and 24 are reviews. ClinicalTrials.gov lists 0 registered studies matching the compound.
- PubMed records
- 462
- Earliest record
- 1977
- Published 2021–2025
- 7
- Reviews
- 24
- Animal-only studies
- 322
- Registered studies
- 0
Publications per year, 2006–2025
13 records in 2016–2025 against 50 in 2006–2015; the busiest year was 2014, with 9.
See the numbers
| Year | PubMed records |
|---|---|
| 2006 | 7 |
| 2007 | 4 |
| 2008 | 6 |
| 2009 | 5 |
| 2010 | 2 |
| 2011 | 4 |
| 2012 | 5 |
| 2013 | 5 |
| 2014 | 9 |
| 2015 | 3 |
| 2016 | 2 |
| 2017 | 2 |
| 2018 | 1 |
| 2019 | 0 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 0 |
| 2023 | 1 |
| 2024 | 2 |
| 2025 | 1 |
Study types
| All PubMed records | 462 |
|---|---|
| Reviews | 245% |
| Animal studies (no human subjects indexed) | 32270% |
| Indexed as clinical trials | 184% |
| Registered on ClinicalTrials.gov | 0 |
Categories overlap and follow PubMed’s own indexing; recent records may not be indexed yet.
Primary research directions
What 5 of the most-cited and most recent DSIP papers report, in their own authors’ terms. Each line links the paper it came from.
This review of therapeutic peptides in orthopaedics groups delta sleep-inducing peptide with agents the authors describe as targeting circadian and mitochondrial regulators, and notes that although preclinical studies are promising, there is a current lack of clinical trials.
ReviewRahman OF 2026Journal of the American Academy of Orthopaedic Surgeons. Global research & reviewsPMID 41490200
This review describes DSIP as one of four sleep factors identified through classic transfer experiments in animals, but states that a physiological sleep regulatory role has not been determined for these substances.
ReviewObal F 2003Frontiers in bioscience : a journal and virtual libraryPMID 12700031
This review of neuropeptides and human sleep reports that GHRH, galanin and several other peptides promote sleep in human studies, while the impact of delta sleep-inducing peptide on human sleep regulation is not yet clear.
ReviewSteiger A 1997SleepPMID 9456470
This update reviews reports of sleep-inducing and sleep-supporting effects of DSIP in animals, work evaluating its potential therapeutic uses and studies of DSIP-like material in the body, and states that its physiological functions and mechanism of action remain to be established.
ReviewGraf MV 1986PeptidesPMID 3550726
In freely moving rats, a comparison of five putative sleep substances found that delta-sleep-inducing peptide was rapidly associated with increases in both slow-wave sleep and paradoxical sleep, but the effects were not long-lasting.
RatsInoue S 1984Proceedings of the National Academy of Sciences of the United States of AmericaPMID 6592612
Most-studied topics
The Medical Subject Headings (MeSH) PubMed indexers most often marked as a main topic, across 400 of the 462 records. They describe what the literature is about, not what DSIP does.
- Delta Sleep-Inducing Peptide260 papers
- Brain49 papers
- Sleep39 papers
- Stress, Psychological26 papers
- Neuropeptides19 papers
- Neurotransmitter Agents17 papers
- Anticonvulsants17 papers
- Brain Chemistry15 papers
Key papers
Earliest indexed record
Monnier VM (1977). Experientia. Supplementum.
PMID 891716Most-cited paper · 219 citations
Obal F Jr (2003). Frontiers in bioscience : a journal and virtual library.
PMID 12700031Most-cited #2 · 175 citations
Brundin L (2007). European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
PMID 17346943Most-cited #3 · 132 citations
Saus E (2010). Human molecular genetics.
PMID 20656788
Citation counts from NIH iCite, among the 400 records sampled. Titles are left out; open each record on PubMed to read it.
Identity
| Synonyms and codes | Delta sleep-inducing peptide, Emideltide |
|---|---|
| Description | Nonapeptide (9 amino acids) |
| Supplied form | Lyophilized powder |
| CAS number | 62568-57-4 |
| Molecular formula | C35H48N10O15 |
| Molecular weight | 848.8 g/mol |
| Sequence | WAGGDASGE (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) |
As published by Vanta Labs, with its sources, on the DSIP page.
How these numbers were counted
- PubMed search, run November 1, 2026:
"delta sleep-inducing peptide"[tiab] OR "delta-sleep-inducing peptide"[tiab] OR DSIP[tiab]re-run it. Study types add PubMed’s own filters (review, clinical trial, animals not humans). - Topics: MeSH major-topic headings counted across up to 400 of the matching records; headings for study set-up (species, sex, age) are left out.
- Citations: NIH iCite citation counts for the same records.
- ClinicalTrials.gov search:
"delta sleep-inducing peptide"re-run it. Any phase, any status.
This page reports what has been published and what papers say they found, with each source linked. It gives no dosing or usage information, and nothing here is a reason to use DSIP outside a laboratory.
Wholesale supply
DSIP for research, documented lot by lot.
10mg vials, with a published report printing 99.678% HPLC purity. Every wholesale lot comes with its certificate of analysis, and your quote names the lot. Pricing on inquiry.
DSIP research questions
How much research has been published on DSIP?
PubMed indexes 462 records matching DSIP (searched November 1, 2026), including 24 reviews and 18 records indexed as clinical trials. 7 were published in the five years 2021–2025.
When was DSIP first described in the literature?
The earliest PubMed record matching DSIP is from 1977 (Monnier VM, Experientia. Supplementum, PMID 891716).
What topics does the DSIP literature cover?
The subject headings PubMed indexers most often marked as a main topic of DSIP papers are Delta Sleep-Inducing Peptide, Brain, Sleep, Stress, Psychological. These describe what the literature is about. Findings from individual papers, with their sources, are summarized on this page.
What is the regulatory status of DSIP?
DSIP (emideltide) is not listed as an approved drug in the FDA's Drugs@FDA database (searched 24 September 2026).
Is DSIP sold for human use?
No. Vanta Foundry supplies it for laboratory research use only. Not for human or veterinary use, and not a drug, food, cosmetic or dietary supplement.
Where can I buy DSIP wholesale for research?
From the Vanta Foundry wholesale catalog: add it to your list, choose sizes and the number of vials, and send it on WhatsApp or by email. Every wholesale lot comes with a certificate of analysis.
Research materials supplied by Vanta Foundry are for laboratory research use only. They are not for human or veterinary use and are not drugs, foods, cosmetics or dietary supplements. Websites and payment processing are business services for research-supply brands.
All compounds: research peptide publication statistics.